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Description
Evidence That Metformin Exerts Its Anti-Diabetic Effects Through Inhibition of Complex 1 of the Mitochondrial Respiratory Chain

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Efficacy in Weight Loss Both medications are used for weight management, but Tirzepatide has shown slightly higher effectiveness
Post-RYGB it has been assumed that there is little neuromuscular control on gastric emptying since the pylorus is bypassed [although this may not be correct (45)]
