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This makes sense given the mechanism: slowing gastric emptying and altering gut hormone signaling naturally affects the digestive tract
In subsequent Phase 2 trials, once-weekly subcutaneous injections of retatrutide at doses of 4 mg, 8 mg, and 12 mg resulted in marked improvements in glycemic control compared to placebo, along with substantial weight loss when contrasted with placebo and dulaglutide (1.5 mg)
Figure 4 shows the results of SURPASS-4 by tirzepatide dose as well as for all doses pooled, compared to insulin glargine treatment
doi: 10.1186/s13048-021-00867-0 20 DengHChenYXingJZhangNXuL
