3rd generation glp 1 agonist third Understanding the Next-Gen Weight Loss Drug: Retatrutide (GLP-1, GIP, and GLP-1R Agonists for Weight Loss
Description
GLP-1 inhibits adenosine triphosphate (ATP)-regulated potassium (K + )channels, increases activity of L-type voltage gated calcium channels, and triggers opening of non-specific cation channels through PKA and exchange protein directly activated by cAMP (EPAC), two cAMP-dependent processes [48], [49]
Understanding these differences gives you the vocabulary to have an intelligent conversation with your prescriber
Darren K
Bioavailability is low (~1%), but the dose (7 mg or 14 mg daily) is sufficient to have clinical effect
