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Without these habits, tapering off the drug often leads to weight rebound, Funsten says

They are derived from patterns observed across hundreds of trial participants and from the pharmacological profile of the drug

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The GLP-1 RAs appear to modify atherosclerosis in the arteries, much like statin medications that treat cholesterol, and takes about a year or more to demonstrate measurable benefits on risk for cardiovascular events, whereas the SGLT2i medications seem to affect heart and kidney function more prominently and faster, with benefits evident very soon after starting the medication
