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The dual mechanism produces greater appetite suppression and metabolic effects than GLP-1 agonism alone, which explains the superior weight loss results

Titration pacing matters In the Phase 2 NEJM trial, GI side effect rates nearly doubled when participants jumped to 8 mg instead of climbing gradually from 1-2 mg

This gives us a far more complete picture of your health than a standard scale or BMI calculation alone

doi: 10.1016/j.tem.2018.03.003
