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Description
Moreover, we found in our retrospective study that combination of SGLT2is and DPP4is reduced the apical membrane ENaC expression in distal tubules in DKD patients, which was associated with the increase in USE

2,6 SGLT2i represent the first class of HF drugs targeting pathophysiological mechanisms different from neurohormonal activation and providing not only cardioprotective effects but also important metabolic benefits
This mechanism enhances insulin secretion in response to meals, suppresses glucagon release, slows gastric emptying, and reduces appetitecollectively helping to improve glycaemic control and promote weight loss

Es decir, un receptor del sistema digestivo, clave en la regulacin de la insulina que ayuda a procesar la glucosa
