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Description
A team of researchers developed a nanostructure-based GLP-1R agonist capable of crossing the BBB that significantly attenuated neuroinflammation and memory loss in an A peptide-induced mouse model of AD by inhibiting the inflammatory responses of microglia and astrocytes (Zhao et al., 2022)
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Both GLP-1 and its long-lasting analog, exendin-4, can induce anxiety-like behavior in male rodents when administered acutely (95)