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Weeks 5 through 8: the 0.5 mg transition Doubling the dose brings the first meaningful changes for many users

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Holmer H, Pozarek G, Wirflt E, Popovic V, Ekman B, Bjrk J, et al

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Incretin agonists have been shown to promote a shift from this neurotoxic M1 state to an anti-inflammatory and neuroprotective M2 phenotype, which releases factors such as IL-10 and BDNF []

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