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Leptin, a hormone that signals fullness, may decrease, while ghrelin, the hunger hormone, may increase

As the use of GLP1 RAs continues to expand rapidly, this risk can impact a substantial number of patients at the population level

(8) Excess body weight increases the mechanical load on weight-bearing joints, accelerating cartilage wear and joint degeneration, and contributing to a pro-inflammatory state that further exacerbates joint damage

Delayed gastric emptying, gastroparesis-like symptoms, intestinal obstruction, biliary disease, and pancreatic safety concerns were variably reported, with heterogeneous and sometimes conflicting evidence across studies