tirzepatide sglt2 Once-weekly versus once-daily insulin degludec as add-on to metformin with or without inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial A summary of the beneficial
Description
Individual susceptibility varies based on factors including dosage, concurrent medications, and underlying health conditions
Generally no

If treatment is restarted later, your medical provider may adjust the dose depending on how long you were off the medication

According to the FDA prescribing information for Zepbound, in the SURMOUNT-1 trial, cholelithiasis was reported in 2.5% of patients receiving tirzepatide compared to 1.0% of patients on placebo
