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Semaglutide produces significant initial weight loss in many patients, yet approximately 20-30% experience a plateau within 6-12 months despite consistent medication use

The SUSTAIN trial series, which established semaglutide's safety and effectiveness, used a once-weekly protocol exclusively

doi: 10.1016/j.biortech.2023.129993

True allergic reactions involve the immune system mounting a broader response, potentially affecting skin throughout the body, respiratory function, or cardiovascular stability in extreme cases
