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Helps regulate appetite and feelings of fullness

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Originally developed to treat type 2 diabetes (T2D), these drugs have since delivered major advances in managing obesity and cardiovascular risk reduction

Objective This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework