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Although GLP-1RAs are known to have action in the brain, it is possible one mechanism by which GLP-1RAs reduce consumption of ingested drugs such as alcohol is, at least in part, through peripheral mechanisms

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However, the FDA prescribing information includes a warning about acute kidney injury (AKI) in patients who experience severe gastrointestinal adverse reactions

The outcome measures of interest include average drinks (Poisson distribution) and binge drinking (Binomial distribution) calculated from TLFB, AUDIT scores (Gaussian distribution), alcohol use per episode of use (Gaussian distribution) and the sedative and stimulative scores from the BAES scale (Gaussian distribution)