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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1

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The aim of this review is to provide an in-depth summary of CVOT datacrystallising the key findings, from safety to efficacyand to offer a practical perspective for physicians