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(2025), in Diabetes, Obesity and Metabolism, reported a weighted mean difference of 1.02 kg in lean body mass across 19 RCTs
GLP-1RAs have an impact in reversing vascular remodeling and attenuating the progression of VSMC senescence (Figure 2)
Nausea typically resolves within two months at a stable dose
However, as the effects do not persist over an entire 24 h period, its efficacy at lowering blood glucose levels and reducing body weight is lower than that of GLP-1 receptor agonists with a longer duration of action [3]
