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10.1007/s10620-022-07519-3 58 HolstJ

Semaglutide has transformed weight management by suppressing appetite through GLP-1 receptor activation, with clinical trials showing 1522% body weight reduction over 68 weeks

In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision
