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Effect of Subcutaneous tirzepatide vs placebo added to titrated insulin glargine on glycemic control in patients with type 2 diabetes: the SURPASS-5 randomized clinical trial

Recently, three new axes have been identified, emphasizing the role of the kidney in this picture (22): The ACE2/ANG(1-7)/Mas receptor pathway (23, 24): Ang-(1-7) binds to the G protein-coupled receptor Mas, which is expressed in renal proximal tubular cells, afferent arterioles, cardiac myocytes, and neuronal cells

Supplementing with magnesium can help to address this underlying cause and reduce (and prevent) headaches, muscle cramps, and pain
