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Second, some baseline characteristics, such as included population, duration of study, background therapies and quality of studies are different across included RCTs which are particularly relevant as cardiometabolic effects of GLP-1RAs may differ when these agents are added to insulin, metformin, sulfonylureas, DDP-4 inhibitors and SGLT-2 inhibitors

A larger syringe (1mL or 3mL) with a longer needle (18-21 gauge) for drawing bacteriostatic water and injecting it into the vial during reconstitution

Pharmaceutical semaglutide (Wegovy) costs approximately $1,300 per month without insurance, making Evolv appear more affordable

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