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Similar to findings in male mice, vehicle-treated Glp1r fl/fl and Glp1r Wnt1/ mice showed weight gain or maintenance of body weight, changing by 4.6% and 0.4%, respectively, over the course of treatment

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Compared with placebo, ziltivekimab reduced hsCRP concentrations by up to 92%, prompting the formal cardiovascular outcome trial, ZEUS (NCT05021835)

They speculated that this linkage of worse presenting and final BCVA may be due to the greater virulence of the infectious organisms involved causing more severe visual impairment initially due to toxin release and hence, resulting in poorer recovery