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Description
Four structural regions were considered in our quest to improve GLP-1R agonist activity of small molecule 2 : the piperidine ring (yellow), the benzyl ether (green), the 5-fluoro-pyrimidine (blue), and the benzimidazole (red), as highlighted in Fig
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10.1073/pnas.80.18.5485 80 LovicD.PiperidouA.ZografouI.GrassosH.PittarasA.ManolisA
Eng hypothesized it might produce a hormone to modulate insulin for those big meals ( [78] ) ( [79] )
