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Drug selection is based on a variety of factors, such as other medical conditions, anticipated side effects and drug interactions, and insurance coverage

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To establish whether the MYTHO-WIPI2 interaction occurs on the PtdIns3P-enriched membrane, we expressed in cells a WIPI2 mutant (WIPI2-FTTG), which is unable to bind PtdIns3P, for pull-down experiments

Cardiovasc Diabetol 2020;19(1):154