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Abstract Background Glucagon-like peptide-1 (GLP-1) therapies are highly effective for weight loss and metabolic improvement in obesity and type 2 diabetes management

Still, some are less sensitive to change (e.g., handgrip strength) or not feasible to conduct in a clinical setting (e.g., quadricep isometric strength)

These results warrant further translational exploration of GLP-1R agonists, particularly in individuals for whom metabolic dysregulation and addiction vulnerability converge