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doi: 10.1001/jama.2025.20947
Gastrointestinal effects The most commonly reported side effects in retatrutide clinical trials were gastrointestinal in nature
The colonic microbiota is known to induce fermentation of dietary fiber, resulting in the production of beneficial short-chain fatty acids (SCFAs), including butyrate and propionate
These neurochemical effects are consistent with clinical neuroimaging data showing reduced alcohol cue reactivity and striatal DAT availability in patients receiving exenatide
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