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It remains the leading cause of ESKD in adults, with the global prevalence of DM in adult ESKD patients reaching 29.7% in 2015 [7]

Improving diet, hydration, and micronutrient intake, especially zinc, folate, and vitamin C helps increase sperm density

As a result, several pharmacological agents have been approved to support long-term weight maintenance, some of which include liraglutide, orlistat, and phentermine-topiramate

With the exception of metolazone, thiazide diuretics are considered ineffective when the creatinine clearance is less than 30 ml/minute
