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Design, Synthesis, and Pharmacological Evaluation of Potent Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor (GLP-1R)

Gurung M, Li Z, You H, Rodrigues R, Jump DB, Morgun A, et al

475,480,481 The encouraging results obtained with semaglutide in patients with heart failure and a preserved ejection fraction may provide a new option for this patient population, in which additional therapy, as well as another upstream therapy for patients with a higher BMI who have indications for this condition, is urgently needed

Dietary and Lifestyle Strategies to Support Safe Semaglutide Use Patients using semaglutide with diverticulitis history should prioritize soft, easily digestible foods during the initial weeks of treatment and gradually reintroduce whole grains and high-fiber foods as tolerated