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However, both preclinical 1720 and clinical 21,22 studies largely agree that GIP and GLP-1 are the two primary physiological incretins that mediate nutrient signaling from the intestine to the pancreatic islets, to properly regulate insulin secretion in control of postprandial glucose metabolism

Benjamin Bert, MD , a board-certified ophthalmologist at MemorialCare Orange Coast Medical Center in Fountain Valley, California, added that as GLP-1s help with controlling blood sugar, their use may also lead to changes in vision prescription

Common side effects like nausea, vomiting, diarrhea and appetite suppression can persuade folks to stop therapy altogether, and many GLP-1 benefits fade when treatment stops