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The pooled analysis demonstrated a significant reduction in cardiovascular mortality (HR (95% CI): 0.87 (0.800.94)
Long-Term Use Data and Adherence In terms of adherence, semaglutide and tirzepatide have been associated with high adherence rates despite their respective once-weekly dosing

A nationwide Danish retrospective cohort study indicated that GLP-1 RAs may offer protection against lower extremity amputations in patients with T2DM, compared to sulfonylureas [98]
Some people notice changes within a few weeks, while for others it takes a bit longer
