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There is also a risk of bowel obstruction that is at an even higher risk in patients already prone to gastrointestinal issues

GLP-1RAs reduce food intake and body weight by acting primarily in the brain, but theres a debate about where in the brain these drugs work

A systematic review that pooled data across this drug class, including Retatrutide itself, found that women lost more weight than men and that the gap widened as the total amount of weight loss increased
