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GLP-1 agonists originally appeared as a treatment for people with type 2 diabetes

Circulation, 149(17), e1298e1316

Delphinidin 3-rutinoside (D3R) through GPR40/120 and the Ca 2+ -calmodulin-stimulated protein kinase II (CaMKII) pathway activation stimulates GLP-1 secretion [189]
