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[10] [11] Other potential adverse effects observed with GLP-1 receptor agonists include: Injection site reactions: Redness, swelling, or discomfort at the injection site Fatigue and dizziness: Particularly during the initial treatment period Increased heart rate: A modest elevation in resting heart rate has been noted with GLP-1 agonists [12] [13] Hypoglycaemia: Risk is low when used alone but increases if combined with insulin or sulphonylureas Serious safety considerations require careful monitoring

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DPP-4 inhibitors prevent degradation of GLP-1 thereby increasing its systemic concentration