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It may still occur occasionally, particularly after dietary indiscretions (high-fat meals, excessive alcohol, or unusually large portions), but the chronic, frequent pattern of the escalation phase is typically over

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PubMed Davies M, Frch L, Jeppesen OK, Pakseresht A, Pedersen SD, Perreault L, et al

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[5] This is why GLP-1 receptor agonist drugs cause dramatic reductions in appetite they flood the brain with a much stronger, longer-lasting version of this natural "stop eating" signal

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