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Blood pressure and heart rate should be checked frequently, and any signs of cardiovascular stress should prompt immediate reassessment

Additional file 1: Fig S13)

While liraglutide also showed cardiovascular benefit (13% reduction in the LEADER trial), semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity

Typical Weight Loss Trajectory (based on clinical trial data and real-world reports): First 4 Weeks (Starting Dose): Expected : 1-4 pounds lost (highly variable) Typical Range : Some members lose minimal weight
