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While both GIPRs and GLP-1Rs are present in the CNS, GIPRs are found in regions of the CNS involved in the regulation of food intake, with an expression pattern that does not fully overlap that of GLP-1R [24,25,26]

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Small uncontrolled semaglutide and tirzepatide series suggest that extending the same dose to every other week can hold much of a plateau with less drug and may preserve more muscle than active loss