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Patient B: Jennifer, 43 Starting weight: 242 pounds Height: 57 Exercise approach: No resistance training, some walking, protein intake around 50-60g daily After 11 months: Weight: 168 pounds (74 pounds lost) Body fat: 34% (down from 43%) DEXA scan: 47 pounds fat lost, 27 pounds muscle lost Resting metabolic rate: Dropped 280 calories from baseline Clothing size: 22 to 12 Strength: Not assessed (no baseline) Jennifer looked deflated

During the shortage, licensed compounding pharmacies were permitted to prepare custom-dose formulations when FDA-approved products were unavailable

Inflation Reduction Act provisions may also limit costs but implementation timelines remain uncertain

Why real-world escalation often takes longer In clinical trials, escalation timelines are fixed