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These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall

Amaral SS, Teixeira MG, Brito SL, et al

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doi: 10.1016/S0140-6736(10)60307-8 34 NauckMFridAHermansenKShahNSTankovaTMithaIHet al