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Description
Stephen L
GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation
Increased muscle recovery
Overall, the study supports current guideline flexibility, indicating that both GLP-1RAs and SGLT2 inhibitors provide broadly similar cardiovascular protection
