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Description
Some early studies suggest that semaglutide may lead to hormone changes by helping the body lose weight and reduce insulin resistance
It acts together with locally secreted ghrelin in the hypothalamus to stimulate the NPY and other neurons in the ARC-PVN nucleus to stimulate the appetite
10.1038/mp.2017.91 Mol
Electrolytes like magnesium and sodium also fluctuate with weight loss, further contributing to discomfort
