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Linaclotide acts locally in the gastrointestinal tract with minimal systemic absorption, which contributes to its favourable safety profile

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DAS has received research support from Ethicon Endo-Surgery, Novo Nordisk and Boehringer Ingelheim

[1] [2] This binding triggers several physiological responses: Enhanced insulin secretion : Ozempic stimulates the pancreatic beta cells to release insulin, but only when blood glucose levels are elevated, which reduces the risk of hypoglycaemia [1] [2] Suppressed glucagon release : It inhibits the secretion of glucagon, a hormone that raises blood glucose by promoting hepatic glucose production Delayed gastric emptying : The medication slows the rate at which food leaves the stomach, leading to more gradual glucose absorption Reduced appetite : Ozempic acts on appetite centres in the brain, promoting satiety and often resulting in weight loss Ozempic is available in multi-dose pre-filled pens for weekly administration