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72,73 The increase in intracellular cAMP after GLP-1R activation then activates a guanine nucleotide exchange factor called Epac (Exchange Protein directly Activated by cAMP), which induces PI3K activation followed by Akt phosphorylation

Therefore, randomized placebo-controlled trials in patients with psoriasis comorbid with and without T2DM are also needed to take into account the impact of comorbid diabetes or obesity, the placebo effect as well as the natural course of psoriasis

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The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis