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Disrupted heart rhythm can prevent the blood from being pumped regularly

Repeated episodes of myocardial stunning or chronic low myocardial blood flow can lead to cellular changes such as resorption of the contractile apparatus in order to decrease oxygen demand and allow the myocardial cells to survive

N Engl J Med 334:574579 Amori RE, Lau J, Pittas AG (2007) Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis

In December, the FDA declared Eli Lilly's tirzepatide was no longer in short supply
