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In pancreatic -cells, activation increases cyclic adenosine monophosphate (cAMP) and boosts insulin secretion in a glucose-dependent fashion

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Cell Metab 26:343352.e342 Frias JP, Nauck MA, Van J et al (2018) Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial