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(8) Excess body weight increases the mechanical load on weight-bearing joints, accelerating cartilage wear and joint degeneration, and contributing to a pro-inflammatory state that further exacerbates joint damage

Insurance companies know this, and theyre reluctant to pay for expensive weight loss medications because they wont see the benefits

At this point, domperidone should be preferred over metoclopramide due to the risk of extrapyramidal side effects

Biochem Cell Biol
