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(8) Excess body weight increases the mechanical load on weight-bearing joints, accelerating cartilage wear and joint degeneration, and contributing to a pro-inflammatory state that further exacerbates joint damage

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Insurance companies know this, and theyre reluctant to pay for expensive weight loss medications because they wont see the benefits

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At this point, domperidone should be preferred over metoclopramide due to the risk of extrapyramidal side effects

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Biochem Cell Biol

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