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Transition phase (discontinuationwashoutstabilization): strictly implement clearance times based on drug characteristicsdiscontinue semaglutide for 2 months, tirzepatide for at least 1 month (161), and long-acting formulations like exenatide for at least 3 months (153, 158, 159, 162)

For tirzepatide specifically, this program has narrowed the cost gap with compounded alternatives to the point where the value proposition of compounded tirzepatide is increasingly difficult to justify

In summary, a series of GLP-1-based combination therapies has been found to offer metabolic benefits greater than what is achieved by treatment with each compound alone

Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach