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Thus, the activation of Ras protein 1 and phospholipase C, as well as the activation of the IP3 and diacylglycerol (DAG) pathways (15), induces calcium ion inflow, triggers the exocytosis of insulin particles, and results in insulin secretion (15, 51)

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Peer-reviewed narrative reviews, systematic reviews, randomized controlled trials, observational studies, and preclinical studies (both in vitro and in vivo) focusing on the pharmacology, pharmacokinetics, safety, drug interactions, toxicology, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, cancer and chemical characterization of BBR were considered eligible