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[1] Serious gastrointestinal events were not prominently reported in the available phase 2 data, though the limited duration and sample size of phase 2 studies mean that longer-term phase 3 data will provide a more complete safety picture

Vehicle-treated mice showed rapid weight loss, reflecting the catabolic state of uncontrolled diabetes

It remains unclear whether any perceived worsening is directly attributable to tirzepatide, coincidental, or related to other factors such as stress, dietary modification, or concurrent medications