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However, if they're worsening or are impacting your everyday life, you should talk with your health care provider about different strategies, such as waiting a longer amount of time to increase your dosage." Serious side effects of Zepbound According to the FDA, some serious health issues occurred in clinical trials of people taking tirzepatide, including: Severe allergic reactions Pancreatitis (inflammation of the pancreas) Hypoglycemia (low blood sugar) Severe digestive problems, which could lead to acute kidney injury Gallbladder problems Medullary thyroid cancer The FDA also notes that theres insufficient data about use of tirzepatide in pregnant women when it comes to risk of birth defects and miscarriage, but there is some evidence in animal studies that a fetus could be affected during pregnancy