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Significant reduction in all-cause mortality with Ozempic 1 For adults with T2D and CKD for a confirmatory secondary endpoint: time to first occurrence of all-cause mortality vs placebo when both were added to standard of care 1,2 All cause death 1-3 1-3 cc 2.5% ARR reported at 3 years in pre-specified supplementary analysis

Temperature dysregulationincluding chills, flushing, and feverhas been reported across GLP-1 medications, affecting fewer than 5% of users in major studies

For others, having food already in the stomach actually buffers the nausea and prevents the waves of queasiness that come with an empty stomach plus a GLP-1 agonist

Thermogenic fat burners address the other by increasing energy expenditure