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One second study evaluated exenatide and oxycodone in mice and reported that the systemic injection of exenatide into the NAcc shell reduced oxycodone self-administration and responses in a reinstatement paradigm.164 However, consistent with prior findings, exenatide did not significantly influence the analgesic effects of oxycodone, as assessed by the tail-immersion test.164 Recently, the Icelandic drug monitoring system reported cases of suicidal ideation and self-harm among patients treated with GLP-1RAs, prompting a review by the European Medicines Agency.165 Currently, there is no evidence indicating that GLP-1RAs increase suicidal behavior

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Its Phase 2 obesity trial published in Lancet Diabetes & Endocrinology (2024) showed up to 18.7% weight loss at 46 weeks, while a separate Phase 2 MASH trial demonstrated significant MASH resolution, earning FDA Breakthrough Therapy Designation