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Semaglutide-treated hepatocytes also had increased expression of genes related to adipocytokine signalling, glucagon signalling, AMPK signalling, insulin signalling, and steroid hormone biosynthesis compared to hepatocytes of vehicle-treated animals ( Figure 6E )
Moreover, we anticipate further pharmacovigilance studies, cohort analyses, and clinical trials in the future to develop evidence-based treatment strategies for patients experiencing GLP-1 RA-induced AP
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GLP-1 receptor agonist weight-loss drugs such as semaglutide may protect the cardiovascular system independent of weight loss
