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2003 Jul 15;114(2-3):153-8

Genetic variation in GLP1R (GLP-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), FTO (fat mass and obesity-associated), and MC4R (melanocortin-4 receptor) genes significantly influences how individuals respond to semaglutide versus tirzepatide

Contribution of GIPR agonism The GIPR is expressed in numerous locations throughout the body that potentially impact the metabolic processes that govern glycemic control and body weight (Figure 4) 55

This allows the stimulant and thermogenic effects to align with daily activity levels
